来源: 作者: 字数:1,112 点击数:43     发布时间:2017-12-11 18:36:23


女,博士,教授,1970年6月出生。1988-1992年,中国农业大学动物生理学与生物化学专业本科;1992-1998年,中国农业大学动物生理学与生物化学专业硕博连读;1998-2000年,中国科学院发育生物学研究所,博士后;2000-2009年, 英国雷丁大学(University of Reading),Research fellow。2009年9月到西北农林科技大学生命科学学院工作,入选2009年教育部新世纪优秀人才支持计划。


  动物病毒(如PRRSV, AcMNPV)蛋白的结构功能,病毒-宿主互作关系



  1. Dong S, Liu L, Wu W, Armstrong SD, Xia D, Nan H, Hiscox JA, Chen H*  Determination of the interactome of non-structural protein12 from highly pathogenic porcine reproductive and respiratory syndrome virus with host cellular proteins using high throughput proteomics and identification of HSP70 as a cellular factor for virus replication. Journal of Proteomics 146: 58–69, 2016.

  2. Liu L, Tian J, Nan H, Tian M, Li Y, Xu X, Huang B, Zhou E, Hiscox JA, Chen H*. Porcine Reproductive and Respiratory Syndrome Virus Nucleocapsid Protein Interacts with Nsp9 and Cellular DHX9 to Regulate Viral RNA Synthesis. J Virol. 2016, 90:5384–5398.

  3. Xu X*, Zhou X, Nan H, Zhao Y, Bai Y, Ou Y, H Chen*.  Aggregation of AcMNPV LEF-10 and Its Impact on Viral Late Gene Expression. PLoS ONE 11(5): e0154835, 2016.

  4. Chen J, Xu X, Tao H, Wang Y, Chen H*. Chemical shift assignments of nsp7α from porcine reproductive and respiratory syndrome virus. Biomol NMR Assign. 2016, 10(2):391-394.

  5. Liu L, Lear Z, Hughes DJ, Wu W, Zhou E, Whitehouse A, Chen H*, Hiscox JA* Resolution of the cellular proteome of the nucleocapsid protein from a highly pathogenic isolate of porcine reproductive and respiratory syndrome virus identifies PARP-1 as a cellular target whose interaction is critical for virus biology. Veterinary Microbiology 2015, 176(1-2): 109-119.

  6. Y Wang, Y Mao, X Xu, S Tao*, H Chen* Codon Usage in Signal Sequences Affects Protein Expression and Secretion Using Baculovirus/Insect Cell Expression System. Plos One 10(12): e0145887, 2015.

  7. Fang W, Peng K, Tian J, Xu X, Zhou E, Chen H*  Immune response to Fc tagged GP5 glycoproteins of porcine reproductive and respiratory syndrome virus. Viral Immunology 2014, 27 (7): 343–349.

  8. Liu B, Wang R, Wu F, Xu X, Chen H* Rapid production of HIV-1 neutralizing antibodies in baculovirus infected insect cells. Protein Expression and Purification 2014, 99:87-93.

  9. Xu X, Chen Y, Zhao Y, Liu X, Dong B, Jones IM, Chen H*  Baculovirus superinfection: A probable restriction factor on the surface display of proteins for library screening. Plos One  8(1): e54631, 2013.

  10. Chen H, Xu X, Lin HH, Chen SH, Forsman A, Chapman MA, Jones IM*. Mapping the immune response to the outer domain of a human immunodeficiency virus-1 clade C gp120. J. Gen. Virol. 2008 Oct;89(Pt 10):2597-2604

  11. Chen H, Xu X, Jones IM*. Immunogenicity of the outer domain of a HIV-1 clade C gp120. Retrovirology 2007; 4: 33.

  12. Chen H, Xu X, Bishop A, Jones IM*.  Reintroduction of the 2G12 epitope in an HIV-1 clade C gp120. AIDS. 2005 May 20;19(8):833-5.

  13. Chen H, Gill A, Dove BK, Emmett SR, Kemp CF, Ritchie MA, Dee M, Hiscox JA*. Mass spectroscopic characterization of the coronavirus infectious bronchitis virus nucleoprotein and elucidation of the role of phosphorylation in RNA binding by using surface plasmon resonance. J Virol. 2005 Jan;79(2):1164-79.

  14. Chen H, Coote B, Attree S, Hiscox JA *. Evaluation of a nucleoprotein-based enzyme-linked immunosorbent assay for the detection of antibodies against infectious bronchitis virus. Avian Pathol. 2003 Oct;32(5):519-26.

  15. Chen H, Wurm T, Britton P, Brooks G, Hiscox JA *.  Interaction of the coronavirus nucleoprotein with nucleolar antigens and the host cell. J Virol. 2002 May;76(10):5233-50.

  16. Chen HY, Zhou Q, Zhang MF, and Giambrone JJ *. Sequence Analysis of the VP2 Hypervariable Region of Nine Infectious Bursal Disease Virus Isolates from Mainland China. Avian Diseases 42:762-769, 1998.    


  陈红英,许晓东,杨雄 一种识别HIV-1受体结合表位的可溶性单链抗体的制备方法,专利号:ZL 2013 1 0088900.1。


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